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99,167 grants found
Showing 181 – 200 of 99,167 grants
An RNA editing platform to investigate the dynamic RNA interactome
PROJECT SUMMARY/ABSTRACT A major mechanism of post-transcriptional gene expression regulation occurs through the binding of RNA transcripts with RNA-binding proteins (RBPs), a larg...
Structure and Mechanism of the Glucose-6-Phosphatase Catalytic Subunit 1
Project Summary This proposal requests support for investigating the structure and enzymology of glucose-6-phosphatase catalytic subunit 1 (G6PC1), an integral membrane protein of...
Health and economic consequences of changing federal and state policies on reproductive health.
PROJECT SUMMARY In June 2022, a decision by the U.S. Supreme Court ended the federally protected right to abortion established by Roe v Wade almost 50-years ago. In response to thi...
Leveraging Medical Records to Understand the Underreporting of Abortion Before and After Dobbs
ABSTRACT Dobbs v. Jackson’s Women’s Health Organization, the U.S. Supreme Court’s 2022 reversal of Roe v. Wade, is the most consequential policy change for maternal and child healt...
Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation
OVERALL PROGRAM SUMMARY: Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation The microbial community (microbiota) in the human gut plays a cent...
Administrative, biospecimen and biostatistical core
SUMMARY CORE A: Administrative, Biostatistics, Clinical and Bionutrition Core The Administrative, Biostatistics, Clinical and Bionutrition Core of this revised application will pro...
Genetics Core for Mucin Degrading Bacteria
SUMMARY CORE B: Genetics Core for Mucin Degrading Bacteria The intestinal microbiota comprises diverse bacteria, a subset of which are capable of degrading the host-derived mucins...
Mucin preserving strategies to reduce allo HCT toxicities
PROJECT 1 SUMMARY: Mucin-preserving strategies to reduce allo HCT toxicities Allogeneic hematopoietic cell transplantation (allo HCT) is a standard therapy for a variety of benign...
Akkermansia muciniphila mucolytic and immunomodulatory properties and intestinal GVHD
PROJECT 2: SUMMARY There’s emerging evidence that the genetic diversity of the mucophylic gut commensal Akkermansia muciniphila contribute to this microbe’s overall impact on human...
Dietary fiber, mucin-degrading Bacteroides, and intestinal GVHD
Summary Diet and nutrition are central to the treatment and prevention of many diseases. Diet is also a convenient, non- invasive lever to manipulate the composition and physiology...
Developing RNP-MaP into a broad-spectrum toolset for discovery, definition, and drug targeting of RNA-protein complexes in live cells
ABSTRACT My laboratory is interested in how interactions between RNA and RNA-binding proteins drive diverse biology and disease, and how these RNA-protein complexes might be target...
A community driven modeling approach for identifying community & policy-level interventions to address the impact of structural racism and discrimination on adolescent substance use and mental health
Project Summary Our overarching goal is to identify and assess policy and community-level interventions that counteract the effects of SRD within neighborhoods, schools, and peer n...
How Health Insurance Benefit Design Affects Infertility Treatment and Birth Outcomes
PROJECT SUMMARY One in six people in the United States have infertility, which is treated most effectively with in vitro fertilization (IVF). IVF is a powerful therapy that require...
Systems-level Analysis of Dynamics and Regulation of the Drosophila NF-kappaB/Dorsal Signaling Module
PROJECT SUMMARY ABSTRACT To achieve robust control of cellular decision-making, including differentiation, a quantitative, mechanistic description of signaling pathway dynamics and...
Advancing help-seeking and recovery measures for sexual and gender minority survivors of gender-based violence
Project Summary Research has documented that gender-based violence (GBV; e.g. intimate partner violence, sexual assault, child abuse, hate-motivated violence) disproportionately im...
Frontostriatal Dynamics During Decision-Making
Many neuropsychiatric disorders involve compulsive behavior, including obsessive-compulsive behavior, obesity, eating disorders, alcoholism, and addiction. Compulsive behavior appe...
Ecological momentary assessment of daily minority stressors and cannabis and tobacco co-use among sexual minority young adults
PROJECT SUMMARY Past-month cannabis use and tobacco use, independently, is 2 times higher in sexual minority young adults (SMYAs) (defined here as lesbian, gay, queer, bisexual/bis...
Evaluating culturally appropriate anti-smoking messages for high-risk Asian ethnic subgroups
PROJECT SUMMARY/ABSTRACT Asian Americans (AAs) are the fastest growing racial group in the US and are comprised of over 40 diverse cultural groups. Although the prevalence of smoki...
Universal Database for Neurometabolic Diseases
PROJECT SUMMARY Neurometabolic diseases encompass a wide range of more than 1600 genetic conditions caused by a metabolic defect that results in significant neurological deficits....
CANOE Partnership: Cancer Awareness, Navigation, Outreach, and Equitable Indigenous Health Outcomes
PROJECT SUMMARY/ABSTRACT The CANOE Partnership: Cancer Awareness, Navigation, Outreach, and Equitable Indigenous Health Outcomes U19 Cooperative Agreement is proposed in response t...