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Genetics of CKD and Hypertension-Risk Prediction and Drug Response in the MVP
Genetics of CKD and Hypertension—Risk Prediction and Drug Response in the MVP Chronic kidney disease (CKD) affects 850 million people worldwide. Preventing the development of CKD a...
Mechanisms of Integrative and Conjugative Elements in Oral Bacteria
Project Summary Streptococcus mutans resides in the oral cavity where it is known to initiate the development of dental caries. For this pathogen to thrive in the dynamic and varia...
Testing the effects of a text message caregiver support intervention for Latinos
ABSTRACT Family caregiving for individuals with Alzheimer’s disease and related dementias (ADRD) has a serious emotional, physical, and financial toll. Latino family caregivers of...
Detecting respiratory distress in nursing home patients with advanced ADRD using radio sensors
PROJECT SUMMARY Overview: The proposal aims to advance the science of geriatric palliative care by assessing the feasibility and acceptability of implementing radio frequency (RF)...
Patient Priorities Survivorship Care for Older Women with Breast Cancer
PROJECT SUMMARY/ABSTRACT Although older women derive a similar degree of benefit from breast cancer survivorship guidelines as their younger counter-parts, there are other issues s...
Biological Amyloids in the Mammalian Brain Extracellular Matrix
PROJECT SUMMARY / ABSTRACT The brain extracellular matrix (ECM) plays critical roles in synaptic plasticity including experience/adaptive-based changes in brain function suggesting...
Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults with Chronic Pain
Abstract Chronic pain is common and often inadequately treated in older individuals. Although opioids are often used to treat chronic pain, their use in older adults is associated...
Olfactory targets of alcohol use disorder medications
Project Summary Alcohol use disorder (AUD) is a severe public health problem. Limited FDA-approved pharmacotherapies exist for AUD, and their efficacy is often insufficient. Theref...
Caregiver-assisted pain coping skills training for dementia
Over five million persons in the United States are living with Alzheimer's disease and related dementias (referred to as “persons with dementia” or PWD). Most patients with ea...
Disc-Facet Crosstalk During Spinal Degeneration and Repair
The anterior intervertebral disc and posterior diarthrodial facet joints form what is referred to the three-joint complex of the spine, working in concert to resist large magnitude...
Computational Tools for Predicting and Understanding Knee Pain Spatial Patterns
Project Abstract Osteoarthritis (OA) is the most common musculoskeletal disorder, presenting a large societal burden and affecting over 300 million worldwide. Knee pain in patients...
Searching for the Goldilocks Zone of Innate Immunity in Alzheimer's Disease
Immunoproteostasis refers to the relationship between the immune system, proteinopathies present in many neurodegenerative disorders, and brain cell dysfunction. The relevance of i...
Vaccine induction of Salmonella-specific Th1 memory cells
PROJECT SUMMARY A successful vaccine for systemic Salmonella infections will need to induce Th1 memory cells, but the tissue location and required functionality of these cells is p...
Generation and characterization of a small RNA mutant library in Neisseria gonorrhea
PROJECT SUMMARY/ABSTRACT Gonorrhea, caused by the Gram-negative bacteria Neisseria gonorrhoeae (NGO), is one of the most prevalent sexually transmitted infections worldwide. In 201...
Validation of Closed-Loop Prefrontal Transcranial Magnetic Stimulation in a Non-Human Primate Model
Abstract This project aims to advance transcranial magnetic stimulation (TMS) technologies for psychiatric disorders. TMS outcomes vary among participants, likely due to a lack of...
Structural investigations of coronavirus spike protein
PROJECT SUMMARY The spike (S) protein decorates the surface of coronavirus (CoV) particles such as SARS-CoV-2 and enables CoV's to enter and infect host cells. The S protein i...
The peripheral blood microbiome as a potential biomarker of knee osteoarthritis
Project Summary / Abstract The objective of the proposed research is to better understand how peripheral blood microbiome patterns are associatedwith knee osteoarthritis (OA). Our...
Investigating Neisseria gonorrhoeae double-stranded bacteriophage
Abstract Neisseria gonorrhoeae is an obligate human pathogenic species. A few reports in the literature describe three or four genomic islands encoding potential double-stranded ph...
Indoles from commensal microbiota promote mobility during aging
Abstract: Aging is associated with loss of mobility and infirmity, which accounts for 23% of the total global burden ofdisease in people aged 60-years and older and will only incre...
Evaluation of CMS Transitional Care and Chronic Care Management Services: Bridging the Gap and Maximizing Potential
PROJECT SUMMARY With increasing life expectancy of US population, healthcare systems are faced with the challenge of improving the health of older adults while containing healthcar...