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99,167 grants found
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AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
Abstract This supplement will support ACTIV-2D ACTIV-2D is a master protocol to evaluate the safety and efficacy of investigational agents for the treatment of symptomatic non-h...
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/
Abstract This supplement will support ACTIV-2D ACTIV-2D is a master protocol to evaluate the safety and efficacy of investigational agents for the treatment of symptomatic non-h...
Development of outpatient antiviral cocktails against SARS-CoV-2 and other potential pandemic RNA viruses.
ABSTRACT: The overall platform and objective of the Stanford AViDD Center, “SyneRx,” is to develop outpatient antiviral cocktails against SARS-CoV-2 and other potential pandemic R...
AI-driven Structure-enabled Antiviral Platform (ASAP)
PROJECT SUMMARY/ABSTRACT - Overall SARS-CoV-2 continues to cause severe morbidity and mortality in the ongoing pandemic. Future RNA virus epidemics and pandemics are inevitable....
Center for Antiviral Medicines & Pandemic Preparedness (CAMPP)
SUMMARY The ongoing COVID-19 pandemic has brought to light an urgent need to enhance the therapeutic preparedness for future viral outbreaks and pandemics. The overarching goal o...
QCRG Pandemic Response Program
QCRG PANDEMIC RESPONSE PROGRAM OVERALL SUMMARY The QCRG (Quantitative Biosciences Institute Coronavirus Research Group) Pandemic Response Program is an interdisciplinary program...
Midwest AViDD Center
Overall – Midwest AViDD Center ABSTRACT The Midwest Anti-Viral Drug Development (AViDD) Center was formalized as a direct response to NIAID U19 RFA RFA-AI-21-050 “Emergency Awa...
RAPIDLY EMERGING ANTIVIRAL DRUG DEVELOPMENT INITIATIVE- AViDD CENTER (READDI-AC)
PROGRAM SUMMARY/ABSTRACT Emerging viruses arise suddenly and cause considerable morbidity and mortality worldwide. To prepare for current and future threats, public-private partn...
Metropolitan AntiViral Drug Accelerator
ABSTRACT The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of deaths worldwide. Novel vaccines against SARS-Co...
CoVPN 3005 - Efficacy, Immunogenicity, and Safety of SARS-CoV-2 Recombinant Protein Vaccine with Adjuvant in Adults 18 Years of Age and Older
FOA: PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements Activity Code/Award: UM1/A1068614-15 (parent award) -----------------------------------...
UTMB-Novartis Alliance for Pandemic Preparedness
OVERALL – ABSTRACT Pandemic prevention and preparedness is a major scientific and societal priority that requires sustained and forward looking investments across governmental, n...
Antiviral Countermeasures Development Center (AC/DC)
The Antiviral Countermeasures Development Center (AC/DC) will target pathogens in five families of RNA viruses with significant pandemic potential, with the overarching goal to ide...
Flavivirus and Alphavirus ReVAMPP (FLARE)
SUMMARY. The Flavivirus and Alphavirus ReVAMPP (FLARE) Center will develop and optimize protein nanoparticle, virion-based, and mRNA vaccine platforms, and monoclonal antibody (m...
Paramyxoviridae and Bunyavirales Vaccines and Antibodies Center (PABVAX)
PROJECT SUMMARY/ABSTRACT - Overall Emerging and reemerging pathogenic RNA viruses represent continuous infectious disease and pandemic threats to public health. Among the many gr...
Vaccines and Therapeutic Antibodies to Respiro, Rubula, Peribunya and Phenuiviridae (R2P2)-ReVAMPP
SUMMARY. The Vaccines and Therapeutic Antibodies to Respirovirus, Rubulavirus, Peribunyavirus and Phenuivirus (R2P2) ReVAMPP Center will utilize both well-defined and novel appro...
HIV Vaccines Clinical Trials Network Leadership and Operations Center
This proposal outlines the scientific agenda of the Leadership and Operations Center of the HIV Vaccine Trials Network (HVTN), the collaboration of physician scientists at 64 clini...
Machine learning-enabled design of prototype pathogen vaccines and antibodies
PROJECT SUMMARY – OVERALL: MACHINE LEARNING-ENABLED DESIGN OF PROTOTYPE PATHOGEN VACCINES AND ANTIBODIES We propose a highly synergistic Center focused on developing end-to-end...
Bunyavirus and Picornavirus Pandemic Pathogen Preparedness (BP4) Center
Project Summary Pathogenic picornaviruses and bunyaviruses have an enormous impact on public health worldwide, and our understanding of mechanistic correlates of immunity for mem...
The UCI Vaccines for Pandemic Preparedness Center (VPPC)
Project Summary/Abstract – Overall: The UCI Vaccines for Pandemic Preparedness Center (VPPC) The Mission: "To contribute to human health and well-being by developing agile, safe,...
The Alzheimer's Disease Tau Platform Clinical Trial
PROJECT SUMMARY / ABSTRACT Tau protein is an attractive AD therapeutic target because the amount and anatomical distribution of insoluble tau at autopsy is strongly correlated wi...