Single Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) - Resource Center (U24 Clinical Trial Not Allowed)

The NIDDK and NHLBI seek to advance their mission by a continuation of the Cardiovascular Repository for Type 1 Diabetes (CARE-T1D) consortium. The CARE-T1D biorepository was established in 2020 through RFA-DK-21-010 and has successfully collected, stored and analyzed cardiovascular tissue (hearts, aortas, carotid arteries and kidneys) from organ donors with type 1 diabetes, type 2 diabetes and without diabetes. A consortium was formed in 2024 through RFA-DK-23-021 to carry out research focused on hypothesis driven research on pathogenesis of cardiac disease in T1D using multi-omics and molecular approaches using the CARE-T1D resources. The goal of this funding opportunity is to continue the CARE-T1D resource center and its work in collecting, analyzing and sharing cardiovascular tissue from organ donors with type 1 diabetes, type 2 diabetes and without diabetes; maintaining and expanding the data repository with results from the consortium resources; and coordinating consortium activities.  This research seeks to improve our understanding of cardiovascular disease in type 1 diabetes and the differences with type 2 diabetes and no diabetes to develop therapies to treat this major cause of mortality for people with type 1 diabetes. This is a Forecast for a Single Source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.