Single Source: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Data Translation Center (U54 Clinical Trial Optional)

<p style="margin-left:0in;">The NHLBI intends to publish a Notice of Funding Opportunity (NOFO) to solicit a single application for the renewal of the Data Translation Center (DTC) for an ongoing NHLBI phenomics program, HeartShare.

Pending submission and award of a meritorious peer-reviewed application, the DTC will coordinate the overall project, continue support of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), and curate and analyze existing data from NIH cohorts and trials.

Companion NOFO will support a Clinical Trial Center for new clinical trial activities and up to seven Clinical Centers (RFA-HL-26-026) that will recruit and retain heart failure patients.</p><p style="margin-left:0in;">Applications are not being solicited at this time.

Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO.

Grant authorities that allow NHLBI to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.</p>