HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

<p>The National Institute of Neurological Disorders and Stroke (NINDS), with&nbsp;the National Center for Advancing Translational Sciences (NCATS), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Center for Complementary and Integrative Health (NCCIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)&nbsp;intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the conduct of &nbsp;large-scale, multisite clinical trials (CTs) that will inform clinicians about the efficacy or effectiveness of interventions or management strategies that reduce opioid use, improve functional outcomes and reduce pain across the continuum of acute to chronic pain associated with many types of diseases, conditions, or pain presenting as a disease itself.

This NOFO will be a continuation of the HEAL Initiative Pain Management Effectiveness Research Network (ERN).

The goal of this NOFO will be to expand the suite of evidence-based effective therapeutics to alleviate pain for multiple pain conditions to benefit patients and their families. Applications are not being solicited at this time.

Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.&nbsp; This NOFO will utilize the UG3/UH3 activity code.

Investigators with expertise and insights into this area of performing effectiveness trials for pain management interventions are encouraged to begin to consider applying for this new NOFO.

In addition, collaborative investigations combining expertise in&nbsp;testing existing pharmaceutical, repurposed therapeutics and/or existing devices will be encouraged, and these investigators should also begin considering applying for this application.</p>