Phage therapy for respiratory infections

Funder	Engineering and Physical Sciences Research Council
Recipient Organization	University of Hertfordshire
Country	United Kingdom
Start Date	Sep 30, 2024
End Date	Sep 29, 2028
Duration	1,460 days
Number of Grantees	2
Roles	Student; Supervisor
Data Source	UKRI Gateway to Research
Grant ID	`2925569`

Grant Description

Respiratory infections caused by antimicrobial resistant (AMR) bacteria accounts for the largest proportion of deaths (1.5 million) attributed to AMR, with Staphylococcus aureus and Pseudomonas aeruginosa being major pathogens.

Aerosolized phage therapy has had variable success in treating human lung infections due to challenges in efficient phage delivery.

This project aims to understand aerosolization factors impacting phage stability and activity, and develop inhalable phage active against AMR S. aureus or P. aeruginosa.