Optical spectroscopy to enable screening in the liver transplant theatre

The project is based around the concept of using Raman Spectroscopy as a method to assess the quality of organs prior to transplantation. The sensing is the measurement of metabolic profiles in an effort to determine signatures of organ health. The analysis is in the local, automated processing of spectra in order to reduce their complexity and communicate their contents in a way that quickly informs clinical decision making.

- Using Raman spectroscopy to assess liver quality in a transplant setting.

- Measuring Raman spectra in the liver is complicated by the high background fluorescence of liver tissue and a novel element of this project is using advanced device designs and advanced signal processing algorithms to allow Raman spectra to be collected with a high enough signal to noise ratio.

- Integrating sensing and analysis technology with normothermic perfusion (a technology used to provide better clinical outcomes for transplantation).