The comorbidity of obsessive-compulsive disorder and schizophrenia: the interplay between psychosocial and genetic risk.

Obsessive-compulsive disorder (OCD) and schizophrenia (SCZ) are highly comorbid; however, the mechanisms underlying this comorbidity are not well researched. Using data from Avon Longitudinal Study of Parents and Children (ALSPAC) longitudinal cohort study and the UK Biobank, I will 1) investigate symptom level associations between

OCD and SCZ using network modelling and identify the bridge symptoms that can help explain the co-occurrence of these two disorders; 2) identify common and unique psychosocial risk factors underlying OCD and SCZ; 3) examine polygenic risk scores to assess gene-environment interplay underlying the comorbidity between OCD and

SCZ.