Developing spatially resolved imaging of functional neurochemistry and cell-type specific microstructure in the living human brain

A new generation of Magnetic Resonance Spectroscopy (MRS) tools promise to deliver powerful, novel, in vivo imaging of cell-type-specific microstructure and functional metabolism in the human brain.

However, these new generation tools require a re-engineering of data acquisition and analysis methods to overcome low signal and a lack of spatial specificity.

Therefore, I will advance these novel MRS methods by delivering techniques to simultaneously spatially- and temporally-resolve functional brain metabolism and cell-type-specific microstructure.

This will unlock non-invasive, quantitative imaging measurements of metabolism underlying major healthy brain processes: plasticity, aging, development; as well as disease pathophysiology.

This research will: - develop novel simultaneous spatially- and dynamically-encoded MRS in the human brain with high spatial and temporal precision. - enable these technological leaps by creating a dedicated spectroscopy analysis toolset to overcome the low signal-to-noise. - translate this technology to widely available commodity hardware and cement its use by tracking pharmacologically induced functional and structural plasticity.

I will create a powerful platform to explore novel spectroscopic signal mechanisms and share it through a well-established, open-source, neuroimaging package (FSL). This will enable critical, but previously unanswerable, clinical and basic science questions to be addressed.