Novel Non-invasive Haemodynamic Methods in Heart Failure with Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is prevalent, increasing and has a poor prognosis. Left ventricular (LV) haemodynamic assessment is needed to diagnose and manage patients with HFpEF. The reference method for it is an invasive study and is rarely done due to costs and risks. Doppler-derived velocity is used as a surrogate for LV pressure.

However, because it is based on a number of assumptions, Doppler remains unreliable for detecting increased LV end-diastolic pressure (LVEDP).

I have validated a four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) acquisition which addresses issues with Doppler.

I have further developed an accurate quantification method, which uniquely, measures intra-ventricular blood flow in 4D.

Other advantages are that it does not require any additional hardware and has demonstrated superior associated with LVEDP.

In this Fellowship, I will develop 4D flow techniques for an accurate assessment of LVEDP and pressure-volume loop in HFpEF.

In addition, I will learn from and collaborate with the world-renowned clinicians, software/hardware engineers and modelling experts in academia and industry, to improve the method’s accuracy and applicability.

I will validate the method’s accuracy and generate clinical data to support future clinical trials, clinical translation and patient benefit.