Utveckling av nya syntesmetoder för [18F]-PET-tracers.

Positron Emission Tomography (PET) imaging has emerged as a powerful non-invasive tool for diagnosing, staging, and monitoring various diseases, including cancer, neurological disorders, and cardiovascular diseases.

Consequently, there is an increasing demand for new and improved synthesis methods for [18F] PET tracers.In this project proposal, our objective is to develop novel synthesis methods for ortho-fluorination of arenes using fluoride (F-) as the fluorination source and for ortho [18F] fluorination of arenes for PET tracer synthesis.

Our approach builds on recent findings enabling selective ortho functionalization of arenes, a reaction allowing precise control over the insertion of heteroatoms such as halogens into arenes, ideal for late-stage fluorination of complex molecular structures found in pharmaceuticals. --This work is unprecedented in the literature--.The successful development of these novel synthesis methods will yield significant benefits for the healthcare industry and patients globally by facilitating the efficient synthesis of a wide range of unprecedented [18F] PET tracers, including those with high diagnostic and therapeutic potential.

This advancement will significantly broaden the available radiotracer repertoire, contributing to the progress of PET imaging technology and enhancing our understanding of disease mechanisms at the molecular level.