Host-Virus Interactions and the Epigenetic Control of Non-Self DNA in Chronic Infections

The research project’s purpose is to explore the intricate dynamics of host-virus interactions.

The primary aim is to understand how viral DNA, once integrated into the human genome, is regulated at the transcriptional level.

This understanding is crucial for chronic infections like HIV-1, where the virus becomes a part of the host’s genetic material.

Although HIV-1 is the primary focus of this project, we seek to generalize our finding to other viruses, such as HPV and HBV that also can integrate into the genome.The research will be carried out using state-of-the-art techniques, allowing precise mapping of viral DNA, visualization of chromatin microenvironment at the single cell level, and functional modifications of enginereed proteins.

These techniques will provide unprecedented insights into the dynamics of host-virus interactions.

Contingency plans exist to optimize the possibilities for success.The project is organized around a team of experts in virology, immunology, and epigenetics. We will collaborate with clinicians at Karolinska University Hospital  (Sweden) and Mass Gen Hospital (US).

The project will span over four years, allowing for thorough investigation and analysis.This research has potential to significantly advance our understanding of viral infections and their long-term impact.

By exploring manipulation of epigenetic control mechanisms, the research could pave the way for novel treatment strategies in precision medicine.