Deep tech-driven development of novel immunotherapy for treatment of multiple forms of cancer

Purpose and goal:

The project aims to revolutionize the treatment of a large number of cancers by developing next-generation immunotherapy.

We have discovered that a specific surface protein is upregulated in AML stem cells and protects leukemia cells from being eliminated by the immune system. Preliminary data now show that even some solid tumors overexpress this protein. In this project we therefore want to map which types of cancer express the protein and could thus be treated.

Expected results and effects:

We expect a survey of, for our treatment, relevant forms of cancer as well as an investigation of the degree to which these can be treated with our antibody.

Approach and implementation:

1) Screening of solid tumors: Large-scale immunohistochemistry will be used to investigate in which tumor forms the target protein is expressed.

2) Treatment in vitro: Our antibody against the target protein will be evaluated in cell models of various forms of cancer.

3) Treatment in vivo: Our antibody against the target protein will be evaluated in animal models of various forms of cancer.

4) Combination treatment: We will investigate the effect of combination treatment with existing therapies.