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Innovative Strategy for Targeted Delivery of Precision Medicine Drugs (INSPIRE)
| Funder | Vinnova |
|---|---|
| Recipient Organization | Uppsala Therapeutics Ab |
| Country | Sweden |
| Start Date | May 01, 2021 |
| End Date | Apr 30, 2023 |
| Duration | 729 days |
| Number of Grantees | 1 |
| Roles | Principal Investigator |
| Data Source | Swedish Research Council |
| Grant ID | 2021-01778_Vinnova |
Grant Description
Purpose and goal:
The aim of the project was to synthesizee chemically modified oligonucleotides that are sensitive to stimuli like alkaline phosphatase and esterase. We have developed esterase-sensitive drug-siRNA conjugates and alkaline-sensitive chemically modified siRNA and DisiRNA. Expected results and effects: All our siRNAs are functional in invitro condition tested and the results will be published in due course.
Approach and implementation:
As designed several chemically modified oligonucleotides which are responsive to stimuli responsive were synthesized and successfully decortaed with drug nanoparticles.A systematic characterization and their funtional properties has been studied.
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Uppsala Therapeutics Ab
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