Protein Production Sweden

We propose to establish a national distributed Swedish infrastructure for protein production, Protein Production Sweden (PPS).

The infrastructure will build upon already existing and actively collaborating university facilities for protein production, with complementary expression systems and techniques from some additional labs.

PPS will offer easy and equal access to excellent high-quality protein reagents  for all researchers in Sweden, including those from industry.

We will create a world-class protein production infrastructure in terms of scientific expertise and expression system diversity, combined with state-of-the-art protein purification capabilities and required quality control of the produced proteins.Proteins are important for research in many areas of life science.

Most current drugs act on proteins and protein reagents are needed for drug discovery and development. Proteins can also serve as drugs, vaccine components, industrial enzymes or chemical catalysts. For structural biological studies, the availability of  protein reagents is fundamental.

Sweden has made huge investments to develop its capabilities within the life sciences by establishing national infrastructures like MAX IV, Cryo-EM at SciLifeLab, NMR for Life, BioMS and by contribution to the European Spallation Source.

A necessity for doing world-class protein research at these facilities is the access to high-quality proteins in adequate amounts, something that PPS will be able to deliver.A national infrastructure will also allow Swedish researchers to get expert advice for how the protein should be produced for its intended use.

To accomplish this, the infrastructure will have a common access point, guiding the researcher to the appropriate node for each protein.

This will lead to an excellent availability of protein reagents for all Swedish researchers, which will in turn promote world-class scientific discoveries from experimental studies in many scientific areas.