Systems-level Immunomonitoring of children treated at Astrid Lindgren’s Children’s Hospital

Patients treated for complex diseases are often challenging to interpret, care is multimodal and precision in diagnosis increasingly important. There is also a push for more personalized treatments in advanced healthcare programs.

There are some current examples of data-driven medicine, particularly involving genomics in oncology and congenital disorders but we need functional assessments to complement such genetic data and inform of the functional state of a given individual, its disease and the effects of treatments administered.Here we apply for the establishment of a testbed to bridge advanced technologies available at SciLifeLab with clinical programs at the Astrid Lindgren’s children’s hospital.

We focus on state-of the art immunomonitoring methods applied to pediatric oncology, rheumatology and immunodeficiency patients, to map their immune system states and effects of treatments.

The interface centers around sample collection and processing, transfer to the lab and routines for rapid experimental analyses and reporting of results back to clinical partners in real-time.

This project will bridge the existing gap between technological capabilities in academic labs and the needs of patients in the hospital for better characterization of their disease, their treatment and better monitoring of clinical outcome towards a future of data-driven medicine, not only with respect to genes, but also the functional state of organs and biological systems.