Induce vascular networks in large degradable porous scaffolds by influencing the local microenvironment; spatiotemporal control of growth factors and patterning of mechanical signals

Porous scaffolds have for some time shown potential to help tissue regeneration, but to date only a few engineered tissues have achieved clinical success. This is mainly due to insufficient vascularization within the scaffolds.

We believe that the impaired vascularization in large porous degradable scaffolds would be improved by spatiotemporal control of copper ions, fibroblast growth factors, platelet-derived growth factor and appropriate exposure to external mechanical stimulation.

The project is based on that hypothesis and presents an innovative 3D printed multi-layer scaffold and a unique well-thought out surface-based photoactive method to improve angiogenic sprouting.The project combines competences in polymer chemistry, molecular and functional mechanisms of angiogenesis and vascular biomechanics, including modelling.

This unique combination will make it possible to understand microenvironment parameters important for vascularization, from scaffold fabrication to polymer functionalization and their influence on endothelial sprout location.We seek to build degradable scaffolds that have the potential to transform modern tissue engineering using innovative polymer functionalization, 3D printing and electrospinning combined with biomechanical modelling and advanced cell biology.