National Resource for Advanced NMR Technology

A major part of the scien�fic program of the parent project (1RM1GM148766) is based on the world’s highest field high resolu�on NMR magnet, the 36 T series connected hybrid (SCH). This instrument is opening new fron�ers in the studies of a wide array of biological systems, chemical compounds, and

advanced materials. A groundbreaking field regula�on system was developed and implemented for the SCH which suppresses field fluctua�ons down to 0.3 ppm and has enabled a variety of NMR experiments – as proven by the extensive publica�on record in the last five years. We are ready to take the next step

and enable the SCH to make unmatched measurements of spin-1/2 nuclides in biological systems. This will require speeding up the control loop of the field regula�on system from a rate of 40 Hz to a rate of about 1 kHz. Extensive preliminary tes�ng on our current system has demonstrated the improvement

possible with a faster control loop. To accomplish this increase in speed, we propose to replace our ca. 2013 Na�onal Instruments electronics with the much more powerful 2024 version. The new hardware has the increased FPGA fabric and backplane data transfer capability to make the faster control loop

possible. It also runs a currently supported development environment and will be compliant with ever increasing LAN and internet security requirements. The field regula�on technology developed with the new system may find applica�on in regula�ng nonpersistent NMR magnets based on high temperature

superconductors.