2024 Drug Metabolism Gordon Research Conference and Gordon Research Seminar

Abstract To deeply understand the pharmacology and toxicology of a molecule, whether it be a drug, endogenous chemical, or a natural product, the Absorption, Distribution, Metabolism, and Excretion (ADME) properties for the molecule must be known. ADME has a tremendous influence on efficacy, safety, and dosing of therapeutic

agents. Thus, ADME science is at the core of translating basic science discoveries into effective therapies in the clinic, optimization and individualization of drug therapy, and informing clinical and regulatory decision making. There is unprecedented diversity in the approaches available for research and discovery of new

treatments for disease. The pace of discovery has increased immensely, and an epic expansion of new knowledge and therapeutic modalities is well underway. In this 52nd meeting of the Drug Metabolism Gordon Research Conference we will embrace the foundational character of ADME science as a guiding force in what

is now a multiverse of scientific discovery consisting of grand diversity. ADME science is characterized as being highly integrative, multidisciplinary, and based on structural, mechanistic, kinetic, quantitative, and computational approaches to predict and translate molecular discoveries to effective clinical application. At the

forefront will be the presentation and discussion of research that embraces these foundational characteristics and their application to: 1) metabolite identification, pathways, and distribution, 2) ADME enzymes and transporters, 3) protein degraders, and 4) interpretation/application of fraction unbound for drug clearance

prediction. We will share cutting-edge science and emphasize the importance of interconnectedness among disciplines so that we fully embrace the potential of emerging technologies to inform ADME studies, technologies such as mass spec imaging, cryogenic electron microscopy, new methods for drug-drug

interaction prediction, and microphysiological devices. The conference will bring together academic, industry and regulatory scientists at all career stages and provide a stimulating and welcoming environment to discuss unpublished research. The informal venue with communal dining and housing provides an ideal environment to

establish this. This conference will provide a forum for early career scientists to interact with leaders in their respective fields, expand their knowledge, establish collaborative relationships, and consider various career paths. Scientific sessions are held in the mornings and evenings over 4.5 days with the afternoons available for

informal discussions and recreation. GRC meetings are small and designed for more discussion time during both the formal scientific sessions and during informal interactions (e.g., poster sessions, mealtimes, afternoon outings). To facilitate ample opportunity to discuss their work, the Drug Metabolism GRC organizes four, two-

hour poster sessions, with each poster presenter (at least 60) available for discussion during two sessions. The 2-day Gordon Research Seminar will precede the main GRC conference. It provides a unique environment for students and early career scientist to present, connect and access mentoring.