Harnessing the Malarial Immunity Omics Landscape in Vaccinated and Unvaccinated Children for Improved Therapeutic Strategies

$6.8M USD

Funder	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Recipient Organization	University of New Mexico Health Scis Ctr
Country	United States
Start Date	Aug 01, 2024
End Date	Jun 30, 2029
Duration	1,794 days
Number of Grantees	2
Roles	Co-Investigator; Principal Investigator
Data Source	NIH (US)
Grant ID	`10999914`

Grant Description

PROJECT SUMMARY Malaria is currently rising and continues to pose a significant public health threat, with 249 million cases and 608,000 deaths annually, primarily in sub-Saharan Africa. The disease disproportionally affects children under five years residing in holoendemic Plasmodium falciparum (Pf) transmission regions, who account for 94% of

the cases and 78% of the mortality. Young children, such as our study participants in Siaya, Kenya, are highly vulnerable to developing life-threatening severe malarial anemia [SMA, hemoglobin (Hb)