Cell-free DNA Analysis for Liquid Biopsy of Cancer

$859.3K USD

Funder	NATIONAL CANCER INSTITUTE
Recipient Organization	Stanford University
Country	United States
Start Date	Sep 01, 2023
End Date	Aug 31, 2027
Duration	1,460 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10818662`

Grant Description

PROJECT SUMMARY/ABSTRACT Circulating tumor DNA (ctDNA) which mirrors the parental tumor, is present in the plasma of non-small cell lung carcinoma (NSCLC) patients. Liquid biopsy analysis of ctDNA allows early detection and genetic monitoring. However, current PCR-based liquid biopsy methods often have difficulty detecting ctDNA due to low copies in

circulation. In contrast, the electric field-induced release and measurement liquid biopsy (eLB) platform, detects mutant EGFR (L858R, exon19del, T790M) ctDNA with a >90% tissue-genotype concordance in