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A Vascularized Blood-Brain Barrier Model for In Vitro Testing of Drug and Immunotherapy Delivery
| Funder | NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE |
|---|---|
| Recipient Organization | Aracari Biosciences, Inc. |
| Country | United States |
| Start Date | May 01, 2023 |
| End Date | Apr 30, 2025 |
| Duration | 730 days |
| Number of Grantees | 1 |
| Roles | Principal Investigator |
| Data Source | NIH (US) |
| Grant ID | 10699597 |
Grant Description
PROJECT SUMMARY The brain is a highly-specialized, finely-tuned organ that depends for its function on maintaining homeostasis within narrowly-defined limits. This is achieved in large part by the Blood-Brain Barrier (BBB), which tightly regulates what can and can’t get into the brain. Functionally, the BBB is the combined work of endothelial cells
(EC), pericytes and astrocytes, the latter two of which act on the EC to maintain an extensive network of tight junctions, promote the expression of specialized transporters, and limit the rate of transcellular pinocytosis. This lack of free transfer between blood and brain for non-lipophilic species severely limits the entry of many,
otherwise useful, small molecule drugs. For example, cisplatin (
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Aracari Biosciences, Inc.
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