Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Clinical Translation and Validation Core

PROJECT SUMMARY: Clinical Translation & Validation Core The activities of the Clinical Translation and Validation Core will support the pilot project research process for the Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC) by providing access to state-of-art facilities, consulting services, and intellectual resources to enable validation

and feasibility-testing of AI-enhanced technologies. To achieve these objectives, the Clinical Translation and Validation Core will pursue the following three aims. First, it will provide a streamlined validation pipeline for taking promising AI-enhanced technologies from benchtop to real-world deployment to enable at-home use for older adults and patients with AD/ADRD. To

accomplish this, the Clinical Translation and Validation Core will leverage state-of-art facilities for technology validation at the UMass Amherst Institute of Applied Life Sciences (IALS) and the Northeastern Consortium on Technology for Proactive Care. The Clinical Translation and Validation Core will also provide pilot project

teams the opportunity to recruit participants in both urban and rural settings across Eastern and Western Massachusetts. The Clinical Translation and Validation Core will leverage longitudinal study cohorts already engaged with the Massachusetts Alzheimer’s Disease Research Center (MADRC) and the Harvard Brain

Study (HABS), and ad-hoc cohorts at the Brandeis and Brigham Women’s Hospital Roybal Centers and UMass IALS. Second, the Clinical Translation and Validation Core will support the pilot project process by contributing to defining the call for proposals by suggesting AI-enhanced technologies that are suitable for

validation by leveraging MIATC resources (in coordination with the Technology Identification and Training Core). It will also provide input regarding the selection of pilots based on technical, usability, and feasibility criteria and offer consulting services and technical support to enhance likelihood of pilot project success. Third,

the Clinical Translation and Validation Core will maintain a continually evolving knowledge base of emerging advances in AI-enhanced technologies that have the potential to significantly improve Healthy Aging and AD/ADRD care. This database will summarize the key strengths and weaknesses of these technologies and

the types of settings where each technology could be used. The Clinical Translation and Validation Core will also facilitate pairing of technology developers with clinical researchers and other stakeholders with interest in validating AI-enhanced technologies. The activities of the Clinical Translation and Validation Core will increase

the impact of the pilot project program by providing teams with resources to bridge the gap between research and implementation in real-world settings.