Epigenetic control and probabilistic disease programming

$5.23M USD

Funder	NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Recipient Organization	Van Andel Research Institute
Country	United States
Start Date	Sep 22, 2021
End Date	Aug 31, 2023
Duration	708 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10372588`

Grant Description

PROJECT SUMMARY Dogma teaches that an individual?s phenotype (and disease) results from genetics, the environment, and their interactions.

Yet numerous studies of monozygotic human twins and isogenic animal models indicate that significant portions of disease variability cannot be explained by genetic and environmental inputs. For example, genetics accounts for ~50% and environment accounts for