Single cell quantification of genomic instability in cancer as a determinant of therapeutic response

PROJECT ABSTRACT Tumor genetic heterogeneity is an extensive feature of cancer biology and underlies patient response to therapy. One aspect of tumor heterogeneity that has been difficult to study is heterogeneity of large genomic aberrations, including high level amplifications a few megabases in size, whole or partial chromosomal gains

and losses and whole genome duplications. This is because identifying these aberrations in subclonal populations (present in