An integral solution for quantifying intracellular lipid transport using close to native lipid probes.

Dysregulation of lipid transport and metabolism is at the center of many diseases.

Despite its crucial role, gaining a full understanding of lipid transport remains challenging as visualizing lipids and their transport by microscopy is almost impossible.

By providing technological solutions to this problem, we envision to enable new therapeutic strategies with the corresponding benefits for society at large.

A better understanding of lipid transport can help guide the design of drugs to for example treat fatty liver disease, which is estimated to affect up to quarter of the global population.

During the ERC PoC grant period, we plan to translate our current protocols to high throughput screening setups with the goal to service the pharmaceutical industry and design ready-to-use kits and devices that will allow academic laboratories to answer their unique research questions.