Multi-modal chemical probes as diagnostic tools

Funder	European Commission
Recipient Organization	Katholieke Universiteit Leuven
Country	Belgium
Start Date	Oct 01, 2023
End Date	Sep 30, 2025
Duration	730 days
Number of Grantees	1
Roles	Coordinator
Data Source	European Commission
Grant ID	`101109192`

Grant Description

The overall goal of this project is the detection and imaging of the serine protease TMPRSS2.

The first chemical part focuses on the design and synthesis of ""multi-modal"" chemical probes to visualise serine proteases, in particular TMPRSS2.

The then obtained smart activity-based probes will be used to complete the goal of the biomedical part of the project, which is of TMPRSS2 in a mouse model for colorectal cancer (CRC) and in blood samples of CRC and prostate cancer patients. Successful execution will lead to new diagnostic tools to detect TMPRSS2.

The chemical tools will be readily applicable to other serine proteases as well, whereas the specific TMPRSS2 probes may also be used in other cancer types.