The contribution of thalamocortical projections to high cognitive functions (speech processing, working memory and attention) in sighted and unsighted populations

The proposed project aims to investigate the contribution of thalamocortical projections to high cognitive functions such as speechprocessing, working memory and attention in sighted and unsighted populations.

In the last decades, advances made in magneticresonance imaging (MRI) have shed light on the cortical regions subserving these processes. However, less research has investigatedthe role of thalamocortical pathways in these high cognitive functions.

This could be due to the lack of detailed probabilistic atlases ofthe human thalamus or the small size of the thalamic nuclei as compared to regular voxel sizes.

Therefore, the recent creation of thefirst probabilistic atlas of the human thalamus (developed by the host group), opens the door to investigate to what extentthalamocortical connections relate to speech processing, working memory and attentional abilities.

We will further investigatewhether the involvement of thalamocortical projections in the abovementioned functions differ between sighted and unsightedindividuals, since research conducted in blind population has reported enhanced auditory processing at the thalamic level, alteredthalamocortical connectivity and superior skills in the previous cognitive functions.

To address these scientific questions, we will use amultimodal MRI approach that combines functional and structural MRI indexes with behavioral measures.

Using regression models,we will assess the degree to which thalamocortical connections help to further explain speech processing, working memory andattentional abilities as opposed to just considering cortical indexes, as it was done in the past.

The results of the present researchproject may have important implications as they could open a new avenue at the theoretical level (updating pre-existing models oncognitive neuroscience and creating new ones) and regarding their application (improving the diagnosis and treatment in cases ofaphasia, dementia or attentional deficits)