Time-based single molecule nanolocalization for live cell imaging

€2.5M EUR

Funder	European Commission
Recipient Organization	Centre National de la Recherche Scientifique CNRS
Country	France
Start Date	Nov 01, 2023
End Date	Oct 31, 2028
Duration	1,826 days
Number of Grantees	1
Roles	Coordinator
Data Source	European Commission
Grant ID	`101098103`

Grant Description

Despite the tremendous advances in single molecule localization microscopy mainly obtained on fixed cells, a major step is highly needed to transform it into a genuine live-cell nanoscopy allowing to understand biological processes in their full multi-scale nature from the individual molecule, to the cell, to the multicellular tissues.

Currently, there is no solution to image with an acquisition speed compatible with the dynamics of living cells (>kHz), over a large volumes (>10000 m3), with a significant in-depth imaging capability (>10 m) without compromising the resolution (