Antiviral Proteins Applied as Therapeutics in Aquaculture

In the last decades aquaculture seems to be the only real alternative for global fish food supply.

At present, the aquaculture world production has reached 82.1 million tons worldwide representing the fastest growing animal production sector in the world.

Among aquaculture species, salmonid aquaculture, trout and salmon species, are the highest-value species for global and European aquaculture.

The biggest global constraint to aquaculture production is disease with an estimate of a 10% of all cultured aquatic animals lost because of infectious diseases, amounting to >10 billion USD in losses annually on a global scale.

Among infectious diseases, viral outbreaks are a serious concern, since they are an impediment to the development, productivity, and profitability of fish farms. Intensive fish farming amplifies diseases caused by bacteria, viruses, and parasites, resulting in severe losses. Few vaccines are available for viral diseases in aquaculture and they are not completely effective.

Moreover, up to date there are not antiviral therapeutic treatments to mitigate the outbreaks in unvaccinated fish or to diminish the percentage of losses do not covered by prophylactics vaccines.

During my ERC Starting Grant our group identified a number of antiviral proteins in rainbow trout nucleated red blood cells (RBCs) implicated in halting viral infections. The OBJECTIVE of this project is to perform a Proof of Concept of the antiviral molecules previosuly identified.

We will evaluate the new business opportunity of introducing a new antiviral therapeutic that decreases viral infection and related economic loss in aquaculture.