Decoding Gut microbiota-modulation of Memory

Our memory is essential for all aspects of our lives. Memories are encoded in the brain by coordinated neuronal activity in the hippocampus.

Disruption of this coordination is associated with neurological/psychiatric disorders such as Alzheimer’s disease and schizophrenia affecting spatial and social memories.

Emerging data suggests that the gut microbiota can influence the brain through the vagus nerve with involvements in an increasing number of mental health conditions including those impairing memory.

However, these associations are correlative and the precise microbiota-vagal effects on brain physiology remain to be defined. Can we decode hippocampal neuronal mechanisms contributing to gut-vagal modulation of memory?

REMEMBER aims to establish an integrative functional definition of two distinct and specialised neuronal pathways arising from the vagus-innervated brainstem which are likely to carry microbiota-initiated information into the hippocampus.

By combining state-of-the-art viral tracing, behavioural tests, microbiome-vagal manipulations and in vivo electrophysiology, I propose investigations of progressive levels of biological complexity.

REMEMBER will bring new insights into the regulation of memory and may pave the way for transformative microbiota- and vagus-oriented treatments for people living with memory decline, addressing a public health priority. I will design an open sharing strategy for the dissemination and communication of my findings to maximise their impact.

This fellowship will provide me with interdisciplinary expertise by complementing my knowledge in neuroscience with microbiome research and it will support my transition to independence at APC Microbiome Ireland.

I will grow my network and gain valuable international training and intersectoral exposure through secondments at Icahn School of Medicine in New York and The Allen Institute for Brain Science in Seattle strengthening my competitiveness for independent group leader positions.