Intracellular Carrier Against Resistant microOrganisms (ICARO)

€3M EUR

Funder	European Commission
Recipient Organization	Arrays-for-Cell Nanodevices Sl
Country	Spain
Start Date	Apr 01, 2022
End Date	Mar 31, 2026
Duration	1,460 days
Number of Grantees	4
Roles	Coordinator; Participant
Data Source	European Commission
Grant ID	`101046927`

Grant Description

Intracellular pathogens and viruses elicit immune responses by presenting their antigens to T cells.

At the same time, they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented to the immune system.

To overcome this problem, the EIC-funded ICARO project proposes to use silicon-based microchips that carry pathogen antigens and can be internalised by immune cells to aid antigen presentation.

These biochips are retained within cells for a long time and will provide the foundation for a novel vaccination strategy that can boost specific and long-lasting T cell responses.

The consortium aims to develop standardized methods for ICARO manufacturing and functionalisation to be easily applicable to different pathogens, thus accelerating the generation of new vaccines in the future

All Grantees

Arrays-for-Cell Nanodevices Sl; Interuniversitair Micro-Electronica Centrum; Agencia Estatal Consejo Superior de Investigaciones Cientificas; Centre National de la Recherche Scientifique CNRS